Which of the following is NOT one of the four main large-scale alterations to the genetic code?

The concept of large-scale alterations to the genetic code typically involves significant structural changes to chromosomes that can affect many genes at once. The recognized main types of genetic mutations that fall under this category are deletion, duplication, and inversion.

Deletion refers to the loss of a segment of DNA, which can result in the complete loss of one or more genes. This type of alteration can have a profound impact on an organism's phenotype, as the genes that are deleted are no longer expressed, which could disrupt normal functions.

Duplication involves the repetition of a segment of DNA, which can lead to an increase in gene dosage and might result in the overexpression of certain proteins or functions. Duplicated genes may evolve new functions or contribute to genetic diversity within a population.

Inversion entails the rotation of a segment of DNA by 180 degrees, leading to a situation where the gene order is reversed. This can disrupt the proper functioning of genes if important regulatory sequences are affected or if the inversion breaks a gene into two segments.

Segregation, on the other hand, does not refer to a direct alteration of the genetic code itself but is more about the process by which alleles are separated during meiosis. It defines how different versions of a gene are distributed into